Role of Matrix Metalloproteinases in Vascular Remodeling
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چکیده
منابع مشابه
Metalloproteinases, Mechanical Factors and Vascular Remodeling
Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...
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The extracellular matrix provides a structural framework essential for the functional properties of vessel walls. The three dimensional organization of the extracellular matrix molecules - elastin, collagens, proteoglycans and structural glycoproteins - synthesized during fetal development - is optimal for these functions. In uninjured arteries and veins, some proteases are constitutively expre...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2003
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.10.275